1. enable automatic fire by right-clicking the weapon icon which turns the weapon green
now the weapon will automatic fire on the selected target once you hit spacebar
that is less annoying then to fire each weapon manually and you can concentrate more on your fight
2. use weapon setups which fit your ship
if you use cruisers you should use weapon setups with large angle like phaser banks since you can not turn your ship that fast
if you use escorts you can use weapons with small angle but heavy damage since your ship can turn much better and you can keep your opponent infront of your ship
escorts can also use turrets on the rear weapon slots since they can fire at 360° and assist your forward guns
3. focus on one weapon type
it does not make sense to have phasers, disruptors and other types of weapons mounted at the same time
reason are tech consoles which can boost the effectivity of a specific weapon type
focusing on one type for weapons and tech consoles lead to much higher damage grades
4. make use of your bridge officers
they can do alot of damage with their special abilities or even absorb damage that you would take